Smooth muscle cell differentiation

Across TCGA cell cohorts, RNA activity of the Smooth muscle cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are QKI, FAM110C, and RAB32, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Smooth muscle cell differentiation activity versus QKI in LUNG_SCLC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	QKI →	+1.518	+0.906	.002	.005	3	7
OVARY	FAM110C →	-2.436	-1.127	<.001	.001	3	5
BREAST	RAB32 →	+1.900	+0.797	.002	.004	3	5
BREAST	RORC →	-1.814	-1.015	<.001	<.001	3	4
OVARY	ICA1 →	-2.500	-1.277	<.001	<.001	3	4
BREAST	TTC39A →	-2.641	-0.887	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051145 vs QKI — LUNG_SCLC

Explore this scatter interactively →