Regulation of NK T cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of NK T cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAT_S224, RCSD1, and SERPINB9, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell proliferation activity versus LAT_S224 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAT_S224 →	+0.765	+0.053	<.001	<.001	3	9
GBM	RCSD1 →	+0.606	+0.118	<.001	<.001	3	8
BRCA	SERPINB9 →	+0.483	+0.048	<.001	<.001	3	8
BRCA	ADA2 →	+0.464	+0.048	<.001	<.001	3	8
GBM	CCDC88B_S597 →	+0.720	+0.097	<.001	<.001	3	8
GBM	LCP1 →	+0.854	+0.115	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051140 vs LAT_S224 — BRCA

Explore this scatter interactively →