Regulation of NK T cell proliferation

Across TCGA patient cohorts, RNA activity of the Regulation of NK T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF5LP1, ITGAL, and SP140, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell proliferation activity versus TAF5LP1 in UCEC (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAF5LP1 →	+1.097	+1.202	<.001	<.001	3	9
HNSC	ITGAL →	+1.267	+0.759	<.001	<.001	3	9
HNSC	SP140 →	+1.044	+0.817	<.001	<.001	3	9
HNSC	MAP4K1 →	+1.170	+0.884	<.001	<.001	3	8
HNSC	RASAL3 →	+1.156	+0.901	<.001	<.001	3	8
HNSC	TNFSF8 →	+0.712	+0.739	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051140 vs TAF5LP1 — UCEC

Explore this scatter interactively →