Regulation of NK T cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of NK T cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO18A, DNAJC6, and GPSM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYO18A grouped by Regulation of NK T cell proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MYO18A →	-0.285	-1.670	<.001	<.001	3	5
LUNG_NSCLC_LUSC	DNAJC6 →	-0.193	-0.341	.007	.002	3	4
LARGE_INTESTINE	GPSM2 →	+0.110	+0.298	.009	.004	3	4
LARGE_INTESTINE	ZSCAN9 →	-0.288	-0.399	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	PSMC2 →	+0.373	+0.233	.007	.005	2	5
STOMACH	NCAPH →	+0.368	+0.417	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYO18A by Regulation of NK T cell proliferation activity — SOFT_TISSUE

Explore this box plot interactively →