Regulation of NK T cell proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of NK T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBF4, LAG3, and TYRO3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell proliferation activity versus EBF4 in BLOOD_Leukemia (Pearson r = 1.00).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EBF4 →	+4.315	+2.047	.002	<.001	2	1
BLOOD_Leukemia	LAG3 →	+0.324	+2.018	.008	<.001	2	1
BLOOD_Leukemia	TYRO3 →	+2.980	+2.070	.005	<.001	2	1
BLOOD_Leukemia	CEP170B →	+2.389	+2.053	.003	<.001	2	1
BLOOD_Leukemia	FOXC1 →	+2.755	+1.975	.001	.001	2	1
BLOOD_Leukemia	MTA3 →	+1.325	+2.070	<.001	<.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051140 vs EBF4 — BLOOD_Leukemia

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