Positive regulation of NK T cell activation

Across TCGA patient cohorts, RNA activity of the Positive regulation of NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP15, IKZF3, and PRF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of NK T cell activation activity versus PARP15 in HNSC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP15 →	+0.905	+0.262	<.001	<.001	3	10
HNSC	IKZF3 →	+0.921	+0.249	<.001	<.001	3	10
GBM	PRF1 →	+1.130	+0.345	<.001	<.001	3	10
HNSC	RASAL3 →	+0.946	+0.305	<.001	<.001	3	9
LSCC	TNFSF8 →	+0.754	+0.319	<.001	<.001	3	9
LUAD	CRTAM →	+0.816	+0.254	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051135 vs PARP15 — HNSC

Explore this scatter interactively →