Positive regulation of NK T cell activation

Across TCGA cell cohorts, RNA activity of the Positive regulation of NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC23A2, SYDE2, and FBXL19, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of NK T cell activation activity versus SLC23A2 in BLOOD_Leukemia (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC23A2 →	+0.857	+0.331	<.001	<.001	3	1
BLOOD_Leukemia	SYDE2 →	-1.138	-0.281	<.001	.003	3	1
BLOOD_Leukemia	FBXL19 →	+0.748	+0.255	<.001	<.001	3	1
BLOOD_Leukemia	AFAP1 →	-1.491	-0.239	.006	.004	3	1
BLOOD_Leukemia	ARID5A →	+1.009	+0.303	.006	.001	3	1
BLOOD_Leukemia	ZNF665 →	+1.557	+0.268	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051135 vs SLC23A2 — BLOOD_Leukemia

Explore this scatter interactively →