Regulation of NK T cell activation

Across TCGA patient cohorts, RNA activity of the Regulation of NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCST, ITGB7, and LILRB1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell activation activity versus HCST in GBM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCST →	+0.986	+0.434	<.001	<.001	3	9
LSCC	ITGB7 →	+0.507	+0.328	<.001	.002	3	9
GBM	LILRB1 →	+0.816	+0.383	<.001	<.001	3	8
GBM	IL10RA →	+1.039	+0.292	<.001	<.001	3	8
GBM	BIN2 →	+1.102	+0.529	<.001	<.001	3	8
UCEC	ITK →	+0.752	+0.331	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051133 vs HCST — GBM

Explore this scatter interactively →