Regulation of NK T cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO9, GPATCH4, and C1orf43, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO9 grouped by Regulation of NK T cell activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FBXO9 →	-0.495	-1.230	.004	<.001	3	4
SOFT_TISSUE	GPATCH4 →	+0.964	+1.546	<.001	<.001	2	5
LUNG_SCLC	C1orf43 →	+0.875	+1.625	.007	.001	3	4
LUNG_SCLC	EIF2AK3 →	+0.689	+1.480	.005	.004	3	4
SOFT_TISSUE	FLAD1 →	+0.548	+1.289	<.001	<.001	3	4
STOMACH	WBP1L →	-0.916	-1.556	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO9 by Regulation of NK T cell activation activity — STOMACH

Explore this box plot interactively →