Regulation of NK T cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of NK T cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPA12B, KLF5, and DMBT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSPA12B grouped by Regulation of NK T cell activation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HSPA12B →	+0.323	+0.233	<.001	.001	3	6
LUNG_NSCLC_LUAD	KLF5 →	+0.184	+0.145	.003	.003	3	5
LARGE_INTESTINE	DMBT1 →	+0.223	+0.235	<.001	.001	3	5
KIDNEY	NMRK1 →	-0.143	-0.209	.006	.003	3	4
KIDNEY	THRSP →	+0.182	+0.199	.001	<.001	3	4
BONE	SPRYD4 →	-0.302	-0.291	<.001	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSPA12B by Regulation of NK T cell activation activity — KIDNEY

Explore this box plot interactively →