Regulation of NK T cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A15, DMTN, and RCBTB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell activation activity versus SLC25A15 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SLC25A15 →	+1.276	+0.452	.002	.002	3	5
OESOPHAGUS	DMTN →	+1.464	+0.336	.009	.001	3	5
OESOPHAGUS	RCBTB1 →	+0.954	+0.476	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	RPE →	+1.522	+0.432	<.001	.005	3	5
BLOOD_Myeloma	MT-ND2 →	-1.096	-0.337	.002	.005	3	4
STOMACH	PPARG →	+3.058	+0.515	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051133 vs SLC25A15 — UPPER_AERODIGESTIVE_TRACT

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