Regulation of NK T cell activation

Across TCGA cell cohorts, RNA activity of the Regulation of NK T cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSPH1, TPT1, and PKM, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of NK T cell activation activity versus HSPH1 in LARGE_INTESTINE (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSPH1 →	+2.096	+0.242	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	TPT1 →	+2.667	+0.501	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	PKM →	+1.868	+0.506	<.001	<.001	3	12
SKIN	HSPA8 →	+1.484	+0.362	.001	.007	3	11
LARGE_INTESTINE	EIF4E →	+1.447	+0.243	<.001	<.001	3	11
LARGE_INTESTINE	PFN1 →	+2.118	+0.270	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051133 vs HSPH1 — LARGE_INTESTINE

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