NK T cell activation

Across TCGA patient cohorts, RNA activity of the NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3CG, IL10RA, and BIN2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NK T cell activation activity versus PIK3CG in UCEC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIK3CG →	+0.833	+0.338	<.001	<.001	3	8
HNSC	IL10RA →	+1.149	+0.432	<.001	<.001	3	8
HNSC	BIN2 →	+1.111	+0.496	<.001	<.001	3	8
UCEC	LY9 →	+0.720	+0.337	<.001	<.001	3	8
UCEC	ARHGAP9 →	+0.880	+0.466	<.001	<.001	3	8
HNSC	APOL3 →	+1.189	+0.542	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051132 vs PIK3CG — UCEC

Explore this scatter interactively →