NK T cell activation

Across TCGA cell cohorts, RNA activity of the NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIN1, SNAPC2, and NOA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIN1 grouped by NK T cell activation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RIN1 →	-1.768	-1.586	.001	<.001	3	5
SKIN	SNAPC2 →	-0.392	-0.968	.002	<.001	3	4
OESOPHAGUS	NOA1 →	+0.687	+1.288	.002	.002	3	4
BONE	MFGE8 →	-1.729	-1.777	.009	<.001	3	4
BONE	PLOD1 →	-1.559	-1.312	.009	.001	3	4
BREAST	NAV3 →	-1.403	-0.821	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIN1 by NK T cell activation activity — STOMACH

Explore this box plot interactively →