NK T cell activation

Across TCGA cell cohorts, RNA activity of the NK T cell activation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBP, ARHGEF7, and HDAC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBP grouped by NK T cell activation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TBP →	-0.139	-0.164	.005	<.001	3	5
SOFT_TISSUE	ARHGEF7 →	+0.197	+0.281	.004	<.001	3	4
SOFT_TISSUE	HDAC5 →	+0.266	+0.266	<.001	<.001	3	4
SOFT_TISSUE	GRM6 →	-0.191	-0.363	<.001	<.001	3	4
SOFT_TISSUE	FCHSD2 →	-0.204	-0.300	.005	.002	3	4
LIVER	PPP1R12A →	+0.425	+0.354	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBP by NK T cell activation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →