NK T cell activation

Across TCGA cell cohorts, RNA activity of the NK T cell activation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2K7, CD320, and ST3GAL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NK T cell activation activity versus MAP2K7 in PANCREAS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MAP2K7 →	+0.795	+0.286	.001	.003	2	6
PANCREAS	CD320 →	+1.798	+0.320	<.001	<.001	3	4
OESOPHAGUS	ST3GAL2 →	+1.792	+0.168	.009	.003	3	4
BLOOD_Myeloma	TENT4A →	+0.900	+0.506	.009	.009	3	4
BLOOD_Myeloma	SATB2 →	+1.694	+0.506	.002	.009	3	4
URINARY_TRACT	PPM1F →	+0.935	+0.306	.004	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051132 vs MAP2K7 — PANCREAS

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