Regulation of actin nucleation

Across TCGA patient cohorts, RNA activity of the Regulation of actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEH1L, TMEM229B, and IL18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of actin nucleation activity versus SEH1L in GBM (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEH1L →	-0.188	-0.069	.005	.006	3	4
UCEC	TMEM229B →	+0.738	+0.212	.002	.001	3	3
HNSC	IL18 →	+1.010	+0.323	<.001	.004	3	3
GBM	KIF18B →	-0.828	-0.113	.002	.004	3	3
GBM	PRC1 →	-0.255	-0.071	.002	.005	3	3
GBM	DEPDC1P2 →	-0.287	-0.080	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051125 vs SEH1L — GBM

Explore this scatter interactively →