RNA polymerase II preinitiation complex assembly

Across TCGA cell cohorts, RNA activity of the RNA polymerase II preinitiation complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF10A, GTPBP3, and PDGFC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNFRSF10A grouped by RNA polymerase II preinitiation complex assembly-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TNFRSF10A →	+1.994	+0.391	<.001	.001	3	5
LIVER	GTPBP3 →	-0.888	-0.305	<.001	<.001	3	5
CNS	PDGFC →	-1.050	-0.210	.007	.004	3	5
LIVER	AKAP8L →	-0.923	-0.288	.009	.005	2	5
LIVER	NDUFA13 →	-1.009	-0.282	.005	.007	2	5
PANCREAS	MAU2 →	-0.497	-0.208	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNFRSF10A by RNA polymerase II preinitiation complex assembly activity — STOMACH

Explore this box plot interactively →