Regulation of DNA binding

Across TCGA patient cohorts, RNA activity of the Regulation of DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDCA5, AUNIP, and MKI67, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA binding activity versus CDCA5 in LSCC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDCA5 →	+0.967	+0.197	<.001	<.001	3	6
LSCC	AUNIP →	+0.598	+0.142	.001	<.001	3	5
LSCC	MKI67 →	+0.575	+0.129	.004	.001	3	5
LSCC	E2F1 →	+0.857	+0.157	<.001	.001	3	5
LSCC	CCNF →	+0.490	+0.120	<.001	<.001	3	5
LSCC	PLK1 →	+0.654	+0.170	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051101 vs CDCA5 — LSCC

Explore this scatter interactively →