Regulation of DNA binding

Across TCGA patient cohorts, RNA activity of the Regulation of DNA binding pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRIM33_S862, ZNF318_S2101, and ESF1_S694, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA binding activity versus TRIM33_S862 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRIM33_S862 →	+0.606	+0.590	.001	<.001	3	4
LUAD	ZNF318_S2101 →	+0.863	+0.165	<.001	<.001	3	4
PDAC	ESF1_S694 →	+0.769	+0.355	<.001	<.001	3	4
LSCC	RRP36_S73 →	+0.688	+0.159	<.001	<.001	3	4
LSCC	AURKB →	+0.753	+0.219	<.001	<.001	3	4
UCEC	AKT1S1_T246 →	-0.959	-0.198	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051101 vs TRIM33_S862 — OV

Explore this scatter interactively →