Regulation of DNA binding

Across TCGA cell cohorts, RNA activity of the Regulation of DNA binding pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are URM1, OTUB1, and FAM118B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of DNA binding activity versus URM1 in SOFT_TISSUE (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	URM1 →	+1.028	+0.288	.008	<.001	3	6
BONE	OTUB1 →	+0.835	+0.321	.001	.005	3	6
SKIN	FAM118B →	+0.658	+0.251	.007	.009	3	5
BLOOD_Leukemia	RTEL1 →	+1.034	+0.186	<.001	.005	3	5
UPPER_AERODIGESTIVE_TRACT	FAM117B →	+0.695	+0.303	<.001	.001	3	5
LUNG_SCLC	THYN1 →	+0.768	+0.182	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051101 vs URM1 — SOFT_TISSUE

Explore this scatter interactively →