Positive regulation of binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of binding pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC58, CCDC9B, and NECAP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC58 grouped by Positive regulation of binding-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC58 →	+0.650	+0.980	.009	.003	3	4
LARGE_INTESTINE	CCDC9B →	-2.388	-0.986	<.001	<.001	3	4
SKIN	NECAP2 →	-0.446	-0.639	<.001	.004	3	4
SOFT_TISSUE	TNFRSF14 →	-2.786	-1.260	<.001	.002	3	4
STOMACH	TGM2 →	-4.573	-0.322	.005	<.001	2	4
LUNG_SCLC	SMARCAL1 →	-0.690	-0.283	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC58 by Positive regulation of binding activity — LARGE_INTESTINE

Explore this box plot interactively →