Positive regulation of binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of binding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D30, ARHGAP23, and WNT10A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of binding activity versus TBC1D30 in BLOOD_Myeloma (Pearson r = 0.81).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TBC1D30 →	+3.707	+0.415	<.001	<.001	3	6
LUNG_NSCLC_LUAD	ARHGAP23 →	-1.556	-0.218	.002	.001	3	6
PANCREAS	WNT10A →	-2.762	-0.275	.003	.009	3	6
UPPER_AERODIGESTIVE_TRACT	TRAP1 →	+1.034	+0.256	.003	.003	3	5
LIVER	RMND5A →	+1.394	+0.297	.001	.003	3	5
STOMACH	MARS2 →	+1.075	+0.291	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051099 vs TBC1D30 — BLOOD_Myeloma

Explore this scatter interactively →