Regulation of binding

Across TCGA cell cohorts, RNA activity of the Regulation of binding pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CALR, SAPCD2, and PCDHGA6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CALR grouped by Regulation of binding-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CALR →	+0.173	+0.145	.008	<.001	3	5
BLOOD_Leukemia	SAPCD2 →	+0.241	+0.203	.009	<.001	3	5
SKIN	PCDHGA6 →	+0.272	+0.139	<.001	.001	3	4
BLOOD_Lymphoma	DST →	+0.535	+0.185	.008	.006	3	4
OESOPHAGUS	ANKRD35 →	-0.209	-0.123	.005	.004	3	4
BONE	STK32C →	-0.208	-0.175	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CALR by Regulation of binding activity — CNS

Explore this box plot interactively →