Regulation of binding

Across TCGA cell cohorts, RNA activity of the Regulation of binding pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STIM1, IRF1-AS1, and CCDC9B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STIM1 grouped by Regulation of binding-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	STIM1 →	-1.319	-0.219	.004	.009	3	6
LIVER	IRF1-AS1 →	-1.356	-0.253	.004	.007	3	5
BREAST	CCDC9B →	-1.832	-0.130	.001	.003	3	5
OESOPHAGUS	A4GALT →	-1.769	-0.244	<.001	<.001	2	5
BREAST	PLEKHH1 →	+1.455	+0.139	.004	.002	3	4
LUNG_SCLC	FZD1 →	+1.459	+0.281	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STIM1 by Regulation of binding activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →