Negative regulation of small GTPase mediated signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of small GTPase mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBK, PERP, and DPEP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of small GTPase mediated signal transduction activity versus PBK in LSCC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PBK →	-1.007	-0.691	<.001	<.001	3	5
LSCC	PERP →	-0.701	-0.516	.002	.003	3	5
OV	DPEP2 →	+0.464	+0.784	.009	.003	3	4
OV	TRAV17 →	+0.495	+0.583	.005	.001	3	4
GBM	CKS2 →	-0.694	-0.322	.004	.008	3	4
GBM	P2RY12 →	+0.722	+0.230	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051058 vs PBK — LSCC

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