Negative regulation of small GTPase mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of small GTPase mediated signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELN, ZNF578, and DDX43, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELN grouped by Negative regulation of small GTPase mediated signal transduction-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ELN →	+0.146	+0.083	<.001	<.001	3	6
LUNG_NSCLC_LUAD	ZNF578 →	+0.218	+0.079	.001	<.001	3	5
LUNG_NSCLC_LUAD	DDX43 →	-0.097	-0.063	.008	.001	3	5
LUNG_NSCLC_LUSC	SMARCE1 →	-0.321	-0.097	.004	.002	3	5
BONE	DUSP13 →	-0.283	-0.096	.007	.004	3	5
SOFT_TISSUE	AGT →	-0.244	-0.071	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELN by Negative regulation of small GTPase mediated signal transduction activity — UPPER_AERODIGESTIVE_TRACT

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