Positive regulation of small GTPase mediated signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of small GTPase mediated signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CORO1A, IL16, and DOCK2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of small GTPase mediated signal transduction activity versus CORO1A in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CORO1A →	+0.499	+0.027	<.001	<.001	3	9
BRCA	IL16 →	+0.504	+0.022	<.001	<.001	3	9
BRCA	DOCK2 →	+0.488	+0.030	<.001	<.001	3	8
HNSC	DOCK8 →	+0.459	+0.045	<.001	.003	3	8
BRCA	ELMO1 →	+0.370	+0.030	<.001	<.001	3	8
HNSC	ANKRD44 →	+0.420	+0.048	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051057 vs CORO1A — BRCA

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