Positive regulation of small GTPase mediated signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of small GTPase mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECAP2, HMOX1, and GIMAP8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of small GTPase mediated signal transduction activity versus NECAP2 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NECAP2 →	+0.445	+0.900	<.001	<.001	3	5
UCEC	HMOX1 →	+1.137	+1.035	.002	<.001	2	6
OV	GIMAP8 →	+0.866	+1.022	<.001	<.001	3	4
CCRCC	FAT4 →	+0.575	+0.670	.009	.002	3	4
PDAC	CALD1 →	+0.528	+0.755	<.001	.001	3	4
OV	BMP4 →	+1.234	+0.830	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051057 vs NECAP2 — BRCA

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