Positive regulation of small GTPase mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of small GTPase mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD151, B4GALT1, and TAGLN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD151 grouped by Positive regulation of small GTPase mediated signal transduction-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CD151 →	+1.743	+0.409	.002	.003	3	6
STOMACH	B4GALT1 →	+1.527	+0.370	.001	<.001	3	5
SOFT_TISSUE	TAGLN2 →	+3.837	+0.597	<.001	.007	3	5
URINARY_TRACT	LACTB →	+1.189	+0.264	.002	.001	3	5
LARGE_INTESTINE	DHX33 →	-0.643	-0.336	.002	.001	2	6
LIVER	MYBBP1A →	-1.035	-0.409	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD151 by Positive regulation of small GTPase mediated signal transduction activity — LUNG_NSCLC_LUSC

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