Positive regulation of small GTPase mediated signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of small GTPase mediated signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LARP4, HARS1, and RITA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of small GTPase mediated signal transduction activity versus LARP4 in LUNG_SCLC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LARP4 →	+0.443	+0.200	.006	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	HARS1 →	+0.820	+0.207	.001	.001	3	5
LUNG_NSCLC_LUAD	RITA1 →	+0.323	+0.127	.009	.003	3	5
BONE	BNIP1 →	+0.669	+0.262	.004	.001	3	5
BLOOD_Lymphoma	MRPL16 →	+0.700	+0.218	.002	.002	3	4
BLOOD_Lymphoma	TOMM34 →	+0.817	+0.173	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051057 vs LARP4 — LUNG_SCLC

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