Negative regulation of lipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC00342, GRIPAP1, and SYNJ2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid biosynthetic process activity versus LINC00342 in UCEC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC00342 →	+0.634	+0.090	<.001	.005	3	3
GBM	GRIPAP1 →	+0.224	+0.115	.001	.002	3	3
GBM	SYNJ2 →	+0.708	+0.121	.006	.005	3	3
LSCC	MORC1 →	+0.393	+0.158	.003	.007	3	2
GBM	TRIM3 →	+0.274	+0.156	<.001	<.001	3	2
GBM	MRPL3 →	-0.173	-0.090	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051055 vs LINC00342 — UCEC

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