Negative regulation of lipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A7, EIF5B, and RSAD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC12A7 grouped by Negative regulation of lipid biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC12A7 →	+1.990	+0.891	<.001	.001	3	5
BLOOD_Myeloma	EIF5B →	-0.810	-0.330	.007	.006	3	4
BLOOD_Leukemia	RSAD1 →	+0.884	+1.264	<.001	.001	3	4
OVARY	GLIS2 →	-0.929	-0.814	.001	.009	3	4
PANCREAS	KIF21B →	+0.939	+0.873	.005	.008	3	3
BONE	RPH3AL →	+2.001	+1.615	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC12A7 by Negative regulation of lipid biosynthetic process activity — BREAST

Explore this box plot interactively →