Positive regulation of DNA metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF11, HHEX, and PLP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF11 grouped by Positive regulation of DNA metabolic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KIF11 →	-1.817	-0.202	.005	.005	2	5
URINARY_TRACT	HHEX →	-2.975	-0.251	.006	.003	2	5
BREAST	PLP2 →	+1.048	+0.107	.003	.006	3	4
PANCREAS	USP20 →	+0.904	+0.205	.002	<.001	3	4
LIVER	MOSPD2 →	-1.261	-0.244	.003	.006	3	4
CNS	ACAP3 →	+0.664	+0.109	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF11 by Positive regulation of DNA metabolic process activity — BLOOD_Lymphoma

Explore this box plot interactively →