Positive regulation of DNA metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCAKD, CYBRD1, and IGSF22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA metabolic process activity versus DCAKD in SOFT_TISSUE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DCAKD →	+0.893	+0.143	<.001	.001	3	5
LUNG_SCLC	CYBRD1 →	-1.755	-0.120	<.001	<.001	3	4
LARGE_INTESTINE	IGSF22 →	-0.311	-0.125	.005	<.001	3	4
OESOPHAGUS	ZNF286B →	+0.941	+0.090	.002	.003	2	5
SOFT_TISSUE	KLHL5 →	-1.090	-0.179	.008	.004	3	4
BLOOD_Lymphoma	ARFGEF2 →	-0.717	-0.096	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051054 vs DCAKD — SOFT_TISSUE

Explore this scatter interactively →