Negative regulation of DNA metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of DNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF83, UBE2V1, and ABCD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of DNA metabolic process activity versus ZNF83 in LIVER (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZNF83 →	-3.186	-0.210	.001	.007	3	5
BLOOD_Myeloma	UBE2V1 →	-0.540	-0.146	.002	.006	3	4
LARGE_INTESTINE	ABCD1 →	+1.089	+0.115	.001	.001	3	4
SKIN	ISOC2 →	-0.982	-0.109	<.001	.006	3	4
STOMACH	MED13 →	+0.892	+0.145	.001	<.001	3	4
SOFT_TISSUE	RAB5IF →	-0.718	-0.155	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051053 vs ZNF83 — LIVER

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