Negative regulation of secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAF2, MECP2, and SIPA1L3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRAF2 grouped by Negative regulation of secretion-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TRAF2 →	+1.243	+0.253	<.001	.001	3	5
BONE	MECP2 →	+0.759	+1.745	.008	<.001	3	4
KIDNEY	SIPA1L3 →	+1.364	+0.984	.008	.008	2	5
SKIN	CNPY2 →	+0.440	+0.650	.001	.003	3	4
LUNG_NSCLC_LUAD	PRSS22 →	+2.824	+0.497	<.001	.002	3	4
OESOPHAGUS	CWC22 →	+0.762	+0.290	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRAF2 by Negative regulation of secretion activity — LUNG_SCLC

Explore this box plot interactively →