Negative regulation of secretion

Across TCGA cell cohorts, RNA activity of the Negative regulation of secretion pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL13A, RPS10, and RPP40, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of secretion activity versus RPL13A in URINARY_TRACT (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RPL13A →	-1.137	-0.320	.003	.002	3	6
URINARY_TRACT	RPS10 →	-0.848	-0.269	.004	.001	3	5
URINARY_TRACT	RPP40 →	-1.047	-0.248	.008	<.001	3	5
LUNG_SCLC	TEFM →	-0.535	-0.196	.004	.004	3	5
URINARY_TRACT	RPL28 →	-0.644	-0.219	.003	<.001	3	4
URINARY_TRACT	RPS12 →	-0.725	-0.178	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051048 vs RPL13A — URINARY_TRACT

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