Positive regulation of membrane protein ectodomain proteolysis

Across TCGA cell cohorts, RNA activity of the Positive regulation of membrane protein ectodomain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCRIP2, NRARP, and IQUB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of membrane protein ectodomain proteolysis activity versus MCRIP2 in BREAST (Pearson r = -0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MCRIP2 →	-0.930	-1.113	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	NRARP →	-1.936	-1.223	.002	<.001	3	4
OVARY	IQUB →	+0.308	+0.893	.007	.001	3	4
OESOPHAGUS	IDH2 →	-2.375	-1.213	.003	.005	3	4
BREAST	OPTN →	+1.607	+1.033	<.001	<.001	3	4
BREAST	TNFAIP8 →	+1.026	+0.823	.004	.007	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051044 vs MCRIP2 — BREAST

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