Regulation of endosome size

Across TCGA patient cohorts, RNA activity of the Regulation of endosome size pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNASE1L1, LINC02139, and MYOF, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endosome size activity versus DNASE1L1 in GBM (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DNASE1L1 →	+0.256	+0.171	.008	.001	3	3
BRCA	LINC02139 →	+0.067	+0.280	.001	<.001	3	3
UCEC	MYOF →	+0.702	+0.211	.001	.001	3	2
UCEC	PPBP →	+0.712	+0.237	.001	.008	3	2
UCEC	PHLDA2 →	+0.981	+0.318	.001	.003	3	2
LSCC	TNFAIP6 →	-0.657	-0.165	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051036 vs DNASE1L1 — GBM

Explore this scatter interactively →