Regulation of endosome size

Across TCGA patient cohorts, RNA activity of the Regulation of endosome size pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITPKB_S562, RBM15, and ALS2_S483, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endosome size activity versus ITPKB_S562 in HNSC (Pearson r = -0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ITPKB_S562 →	-1.375	-1.670	<.001	<.001	3	3
BRCA	RBM15 →	-0.216	-0.307	<.001	.005	3	3
UCEC	ALS2_S483 →	+0.604	+0.295	<.001	<.001	3	3
LUAD	SETD2_S624 →	-0.169	-0.170	.004	.002	3	2
LUAD	SLC9A8_T510 →	-0.863	-0.481	<.001	<.001	3	2
CCRCC	SRRM1_S904 →	-0.397	-0.270	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051036 vs ITPKB_S562 — HNSC

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