Regulation of endosome size

Across TCGA cell cohorts, RNA activity of the Regulation of endosome size pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF471, ALDH9A1, and QRSL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF471 grouped by Regulation of endosome size-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF471 →	-0.238	-0.324	.007	.005	3	4
BLOOD_Leukemia	ALDH9A1 →	+0.427	+0.453	<.001	.001	3	4
BONE	QRSL1 →	+0.172	+0.438	.002	.002	3	3
CNS	PIGU →	-0.254	-0.793	.001	.005	3	3
PANCREAS	NAA50 →	-0.376	-1.446	.001	.004	3	3
PANCREAS	GDF11 →	+0.244	+1.633	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF471 by Regulation of endosome size activity — LARGE_INTESTINE

Explore this box plot interactively →