tRNA transport

Across TCGA patient cohorts, RNA activity of the tRNA transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNAJA1_S335, CEBPZ, and NOL6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA transport activity versus DNAJA1_S335 in LSCC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DNAJA1_S335 →	+0.663	+0.036	<.001	<.001	3	7
LUAD	CEBPZ →	+0.245	+0.047	<.001	<.001	3	6
LUAD	NOL6 →	+0.232	+0.054	.001	<.001	3	6
GBM	STOML2 →	+0.530	+0.093	<.001	<.001	3	6
LUAD	RRP36_S73 →	+0.654	+0.043	<.001	<.001	3	5
LUAD	WDR75 →	+0.226	+0.047	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051031 vs DNAJA1_S335 — LSCC

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