tRNA transport

Across TCGA cell cohorts, RNA activity of the tRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUMBL, CANT1, and ZNF564, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUMBL grouped by tRNA transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NUMBL →	+1.270	+0.178	.005	.006	3	4
CNS	CANT1 →	+0.567	+0.350	.003	.008	3	4
LUNG_SCLC	ZNF564 →	-0.715	-0.495	.001	<.001	3	4
BLOOD_Leukemia	NPLOC4 →	+0.670	+0.804	.006	.006	3	3
STOMACH	ZC3H12B →	-0.617	-0.330	.001	.004	2	4
STOMACH	SLC25A53 →	-0.563	-0.331	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUMBL by tRNA transport activity — PANCREAS

Explore this box plot interactively →