snRNA transport

Across TCGA cell cohorts, RNA activity of the snRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF8, GUCD1, and VSTM2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF8 grouped by snRNA transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PRPF8 →	+0.496	+0.136	<.001	<.001	3	5
BREAST	GUCD1 →	+0.714	+0.099	.006	.005	3	5
LUNG_SCLC	VSTM2L →	+2.268	+0.065	.001	.006	3	4
SOFT_TISSUE	NXT2 →	-1.008	-0.113	.002	.002	3	4
OESOPHAGUS	GPSM1 →	+1.528	+0.094	.005	.002	3	4
BREAST	NDUFAF5 →	+0.828	+0.102	<.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF8 by snRNA transport activity — BONE

Explore this box plot interactively →