snRNA transport

Across TCGA cell cohorts, RNA activity of the snRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERLIN1, RETSAT, and GMPPA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, snRNA transport activity versus ERLIN1 in LUNG_SCLC (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ERLIN1 →	-0.671	-0.169	.001	<.001	3	4
LUNG_SCLC	RETSAT →	-0.768	-0.174	.002	.002	3	4
STOMACH	GMPPA →	-0.523	-0.125	<.001	.002	3	4
LARGE_INTESTINE	ULK4 →	+0.712	+0.070	.001	.007	3	3
CNS	RPL4 →	+0.780	+0.112	.001	<.001	3	3
OVARY	SKP1 →	-0.579	-0.093	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051030 vs ERLIN1 — LUNG_SCLC

Explore this scatter interactively →