rRNA transport

Across TCGA patient cohorts, RNA activity of the rRNA transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BRD3, TSC2, and SH3GLB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA transport activity versus BRD3 in PDAC (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BRD3 →	+0.224	+0.047	.001	<.001	3	7
GBM	TSC2 →	+0.156	+0.042	<.001	<.001	3	6
GBM	SH3GLB2 →	+0.431	+0.050	<.001	<.001	3	5
CCRCC	DDX31 →	+0.228	+0.048	.001	.001	3	5
GBM	PTPA →	+0.204	+0.039	.001	.001	3	5
LSCC	RABGAP1 →	+0.218	+0.042	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051029 vs BRD3 — PDAC

Explore this scatter interactively →