rRNA transport

Across TCGA patient cohorts, RNA activity of the rRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYBL2, CDKN3, and FOXM1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA transport activity versus MYBL2 in BRCA (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MYBL2 →	+1.235	+0.186	<.001	<.001	3	7
LUAD	CDKN3 →	+0.919	+0.266	<.001	<.001	3	6
BRCA	FOXM1 →	+1.143	+0.241	<.001	<.001	3	6
LUAD	PKMYT1 →	+0.634	+0.229	<.001	<.001	3	6
BRCA	E2F8 →	+0.702	+0.199	<.001	<.001	3	6
LUAD	GINS2 →	+0.791	+0.223	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0051029 vs MYBL2 — BRCA

Explore this scatter interactively →