rRNA transport

Across TCGA cell cohorts, RNA activity of the rRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFMBT2, TNFAIP3, and NDRG2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SFMBT2 grouped by rRNA transport-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SFMBT2 →	+1.265	+0.315	.006	<.001	3	3
SOFT_TISSUE	TNFAIP3 →	-3.260	-0.386	.003	.006	3	3
KIDNEY	NDRG2 →	+2.742	+0.309	.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	SLCO1A2 →	-1.232	-0.255	.001	<.001	3	2
LUNG_NSCLC_LUAD	TXNDC9 →	-0.890	-0.282	<.001	.008	3	2
LUNG_NSCLC_LUAD	FBXO27 →	-1.830	-0.314	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SFMBT2 by rRNA transport activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →