mRNA transport

Across TCGA cell cohorts, RNA activity of the mRNA transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AARS1, NOB1, and PYCARD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AARS1 grouped by mRNA transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	AARS1 →	-1.288	-0.214	.005	.002	3	5
KIDNEY	NOB1 →	-0.964	-0.212	.003	.002	3	5
LUNG_SCLC	PYCARD →	+2.272	+0.130	.001	.004	3	4
BREAST	ZNF160 →	+0.965	+0.131	<.001	<.001	3	4
OESOPHAGUS	CNIH3 →	+1.483	+0.212	.001	.004	3	4
KIDNEY	LAPTM4B →	-1.157	-0.167	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AARS1 by mRNA transport activity — KIDNEY

Explore this box plot interactively →